The Abandoned Hospital was seen during the events of Resident Evil: Outbreak File #2 in the scenario Flashback. In the early times the hospital was used for those who had become hurt or injured in the Arklay Forest and needed to seek medical attention. It was administered by Albert Lester. Though after his wife became highly ill and was given drugs which contained T-Virus product she was devoured by a large plant which then took over the whole building. But as the building began to age the plant was all that was able to hold the structure together. As it continued to overrun the building it became hungrier for blood and resulted Albert turning into his alter ego known as Axe Man. As Axe man he would lure travelers into the hospital and kill them so he could feed the body of his wife and keep the hospital structure up.
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